Science Inventory

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Background/Purpose The US EPA has developed a tiered testing strategy, including high-throughput transcriptomics (HTTr) testing, to identify molecular targets of thousands of environmental chemicals. These findings can be linked to adverse outcomes and can be used in Integrated A...

To identify U.S. lead exposure risk hotspots, we expanded upon geospatial statistical methods from a published Michigan case study. Evaluation of identified hotspots using six lead indices, based on housing age and sociodemographic data, showed moderate-to-substantial agreement w...

Background: The Toxic Substances Control Act (TSCA) requires the US Environmental Protection Agency (EPA) to evaluate the hazard and exposure to new and existing chemicals. New chemical notifications are typically data poor and EPA?s Office of Pollution Prevention and Toxics (OPP...

Background and Purpose: Adrenergic receptors (AR) are the most extensive therapeutically manipulated drug receptors in the treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary disease. The airways are densely innervated by AR, which are cellular rec...

In-situ burning (ISB) is the controlled burning of oil spilled from a vessel or pipeline. There were multiple ISB events after the Deepwater Horizon oil spill on April 20, 2010, including 410 ISBs conducted by the Coast Guard [1]. Proponents of ISB suggest that it offers a rapid ...

This presentation is to the Research Area Coordination Team (RACT) for the Safe and Sustainable Waters Research program. This work contributes to SSWR Subproduct 404.3.2 Applying forecasted data to better understand, quantify, and anticipate the social and environmental justice i...

Bioaccessibility and relative bioavailability of As, Cd, Pb and Sb was investigated in 30 legacy gold mining wastes (calcine sands, grey battery sands, tailings) from Victorian goldfields (Australia). Pseudo-total As concentration in 29 samples was 1.45–148-fold higher than...

One in 33 babies born in North Carolina (NC) are diagnosed with any birth defect. Little has been done to examine the association between community-level risk factors and birth defects. The objective of this study was to estimate the association of census-tract level neighborhood...

Increasing water shortages and aging infrastructure have broadened interest in using alternative source waters for a range of end uses. Developing fit-for-purpose treatment approaches requires consideration of both the proximal risks of reuse-related exposures and the more distal...

The Bayesian network (BN) session at the SETAC North America 44th Annual Meeting was conducted for the sixth consecutive year. Since its inception in 2018 during the SETAC North America annual meeting in Sacramento, the BN session has grown into a multi-faceted platform for the p...

Read-across is a data-gap filling technique utilised to predict the toxicity of a target chemical using data from similar analogues. Read-across is predominantly performed as part of an expert-driven assessment which can impeded broad acceptance. Data-driven approaches such as Ge...

Background and Purpose: Health effects of inhaled smoke from military burn pits include increased incidences of cardiopulmonary diseases, sinonasal disease, and cancers of the nervous system. Burn pit smoke is a complex mixture of particulate matter (PM), volatile organic compoun...

Background:  Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring...

This invited keynote presentation provides compressive definitions regarding sustainable development, sustainability assessment and design, life cycle analysis, and their application in manufacturing more environmentally friendly chemicals with less occupational exposure. Similar...

Background and Purpose: Particulate matter (PM) air pollution poses significant health risks within and beyond the respiratory system, but the physicochemical characteristics of anthropogenic PM that contribute to toxicity are not well understood. The purpose of this study was to...

Federal agencies are increasing efforts to provide support to local communities for climate adaptation and hazard resilience. This involves engaging communities using approaches to understand and address problems holistically, particularly where equity and environmental justice a...

Seagrass beds play a critical role in biodiversity maintenance, serving as nursery habitats for fisheries, and aiding in carbon and sediment sequestration in the ecosystem. These habitats receive dissolved and particulate material inputs, like nutrients and heavy metals, aff...

Many factors, including microbiome structure and activity in the drinking water distribution system (DWDS), affect the colonization potential of opportunistic pathogens. The present study aims to describe the dynamics of active bacterial communities in DWDS and identify the facto...

Computational fluid dynamics simulations are used to model the velocity field and the transport of a passive scalar within a micro-scale chamber used to measure diffusional transport through various building materials.  Comparisons of solutions obtained using a steady, lamin...

Framing ecological restoration and monitoring goals from a human benefits perspective (i.e., ecosystem services) can help inform restoration planners, surrounding communities, and relevant stakeholders about the direct benefits they may obtain from a specific restoration project....

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Wastewater is a source for many contaminants of emerging concern (CECs) and surface waters receiving wastewater discharge often serve as source water for downstream drinking water treatment plants. Non-targeted analysis and suspect screening methods were used to characterize chem...

Thyroid hormones (TH) are highly iodinated molecules that regulate many aspects of mammalian physiology and are essential for normal growth and development. Deiodinases (DIO) are a family of three metabolizing enzymes (DIO1, DIO2, DIO3) by activating or deactivating TH action. Th...

Background and Purpose:  Consumer products are a major source of chemical exposure and therefore potential risk. It is important to understand what chemicals are typically present in various types of products for risk evaluation and assessment of new products for uncommon ch...

Background and Purpose The U.S. Environmental Protection Agency’s (U.S. EPA) Toxicity Values Database (ToxValDB) is a compendium of toxicology information including human health reference values, cancer slope factors, ecological screening or effect levels, and quantitative ...